1. Name the smallest and largest cell organelle ? 2. Share with your friends Share 8 Ishan Goyal answered this If we consider the surface area as the criteria then the smallest cell organelle is ribosome and the largest cell organelle is nucleus in animal cell & vacuole in plant cell 18 View Full Answer Dharti Patel answered this The smallest cell in the universe is the Mycoplasma, a type of bacteria. Its diameter is 0.1 µm.The smallest cell in the human body, in terms of volume, is the sperm cell. the largest cell of body is nerve cell. 0 Raima Sinha answered this The largest or smallest is dependent upon how you define the terms. In total surface area, the endoplasmic reticulum. 3 Raima Sinha answered this The largest or smallest is dependent upon how you define the terms. In total surface area, the endoplasmic reticulum could be considered the largest. A ribosome could be considered to be the smallest in size 3 Benedict Florance answered this Smallest - RibosomeLargest - Nucleus 6